Hello everyone, and welcome to a new topic! As mentioned before, The Binding of Isaac is one of my favorite video games of all time. With an amazing 547 items, the amount of synergies are literally endless. The following will be a multiple part series on my favorite items, and the awesome synergies that go with it. Now, let’s dive into the basement, and start our crazy adventure!
- (Obvious Choice) Brimstone: Type: Passive Item Cosmetic Change: Transforms Issac into a black demon with red eyes and massive horns. Location: Item Room (Requires some specific items to appear) or Devil Room Effect: Changes Isaac’s tears into a chargeable blood laser that deals his damage for 13 ticks. The laser pierces the entire terrain in a horizontal pattern. If you have 20/20, the beam doubles, and if you have Loki’s Horns, the beam can shoot in a cross-shaped pattern. Lastly, there’s the crazy synergy with Tammy’s Head that literally melts enemies and bosses alike.
Good old Brimstone! This item was first introduced to the game in the Wrath of the Lamb expansion, and I immediately fell in love with it. The laser is a fantastic early game item, and the ridiculous synergies with it can make you win instantly.
- Fruit Cake Type: Passive Location: Item Rooms Cosmetic Change: Issac’s tears are colored like a rainbow. Effect: Every tear that Issac shoots has a random effect ranging from Antigravity to Wiggle Worm. Synergies: Combine this item with 3 Dollar Bill for crazy status effects and unpredictable damage. You can also combine it with any bomb-type item for random bomb effects.
I absolutely adore this item! I love the concept of randomness in video games, and this fits the concept to a T. While it can occasionally backfire and kill you, it’s a blast to pick up on any run.